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PHILADELPHIA, Pa. and OXFORD, UK, July 28, 2016 (GLOBE NEWSWIRE) — Adaptimmune Therapeutics plc (Nasdaq:ADAP), a baton in T-cell analysis to amusement cancer, today appear that the European Medicines Agency (EMA) has accepted admission to its newly-established Priority Medicines (PRIME) authoritative action for the company’s SPEAR® T-cell analysis targeting NY-ESO for the analysis of HLA-A0201, HLA-A0205, or HLA-A0206 allele absolute patients with busted or metastatic synovial bump who accept accustomed above-mentioned chemotherapy and whose bump expresses the NY-ESO-1 bump antigen.

The PRIME action provides abutment to optimize authoritative applications and beforehand the analysis of medicines that abode a aerial unmet need.

“Access to the PRIME action represents an important authoritative befalling for us. It can accommodate aboriginal assurance on the development affairs with abeyant for accelerated appraisal of abstracts to companies like Adaptimmune who are developing new analysis modalities for patients in Europe with few or no analysis options,” said Rafael Amado, Adaptimmune’s Chief Medical Officer. “Our NY-ESO SPEAR T-cell analysis may admonition to abode the cogent unmet medical charge of metastatic or unresectable synovial sarcoma. We attending advanced to alive carefully with the EMA throughout its analytic evaluation.”

Adaptimmune afresh appear that the European Commission had appointed its NY-ESO SPEAR T-cell analysis as an drop alleviative artefact for the analysis of bendable tissue sarcoma. The aggregation has already accustomed drop biologic appellation and Breakthrough Analysis appellation for its NY-ESO SPEAR T-cell analysis from the U.S. Food and Biologic Administration.

The PRIME action focuses on medicines that may action a above ameliorative advantage over absolute treatments, or account patients after analysis options. The belief for the PRIME action crave a anesthetic to appearance its abeyant to account patients with unmet medical needs based on aboriginal analytic data. The action offers aboriginal and proactive abutment to anesthetic developers to optimize the bearing of able-bodied abstracts on a medicine’s allowances and risks and accredit accelerated assessment of medicines applications, and provides arrangement of a rapporteur, aboriginal chat on the all-embracing development plan and authoritative strategy, accurate admonition at key development milestones, a committed point of contact, and the abeyant to authorize articles for accelerated appraisal at the time of an appliance for business authorization.

Adaptimmune’s SPEAR T-cell candidates are atypical blight immunotherapies that accept been engineered to ambition and abort blight beef by deepening a patient’s accustomed T-cell response. T-cells are a blazon of white claret corpuscle that comedy a axial role in a person’s allowed response. Adaptimmune’s ambition is to accouter the adeptness of the T-cell and, through its assorted ameliorative candidate, decidedly appulse blight analysis and analytic outcomes of patients with solid and hematologic cancers.

About AdaptimmuneAdaptimmune is a analytic date biopharmaceutical aggregation focused on atypical blight immunotherapy articles based on its SPEAR® (Specific Peptide Enhanced Affection Receptor) T-cell platform. Established in 2008, the aggregation aims to beforehand the body’s own accouterment – the T-cell – to ambition and abort blight beef by application engineered, added affection TCRs as a agency of deepening accustomed accommodating T-cell responses. Adaptimmune’s beforehand affairs is a SPEAR T-cell analysis targeting the NY-ESO blight antigen. Its NY-ESO SPEAR T-cell analysis has approved signs of adeptness and tolerability in Appearance 1/2 trials in solid tumors and in hematologic blight types, including synovial bump and assorted myeloma. Adaptimmune has a cardinal accord and licensing acceding with GlaxoSmithKline for the development and commercialization of the NY-ESO TCR program. In addition, Adaptimmune has a cardinal of proprietary programs. These accommodate SPEAR T-cell therapies targeting the MAGE-A10 and AFP blight antigens, which both accept accessible INDs, and a added SPEAR T-cell analysis targeting the MAGE-A4 blight antigen that is in pre-clinical appearance with IND accepting targeted for 2017.The aggregation has articular over 30 intracellular ambition peptides preferentially bidding in blight beef and is currently advanced 12 through unpartnered analysis programs. Adaptimmune has over 250 advisers and is amid in Oxfordshire, U.K. and Philadelphia, USA. For added information: http://www.adaptimmune.com

Forward-Looking StatementsThis absolution contains “forward-looking statements” aural the acceptation of the Private Securities Litigation Reform Act of 1995 (PSLRA). These advanced statements absorb assertive risks and uncertainties. Such risks and uncertainties could account our absolute after-effects to alter materially from those adumbrated by such advanced statements, and include, after limitation: the success, amount and timing of our artefact development activities and analytic trials and our adeptness to auspiciously beforehand our TCR ameliorative candidates through the authoritative and commercialization processes. For a added description of the risks and uncertainties that could account our absolute after-effects to alter materially from those bidding in these advanced statements, as able-bodied as risks apropos to our business in general, we accredit you to our Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission (SEC) on May 12, 2016, and our added SEC filings. The advanced statements independent in this columnist absolution allege alone as of the date the statements were fabricated and we do not undertake any obligation to amend such advanced statements to reflect consecutive contest or circumstances.

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