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NEW YORK–(BUSINESS WIRE)–

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Joint studies will appraise one or added of Pfizer’s investigational NASH therapies in aggregate with Novartis’s FXR agonist for the analysis of the accelerating alarmist disease

Pfizer Inc. (PFE) appear today that it has entered into a non-exclusive analytic development acceding with Novartis (NVS) to investigate one or added aggregate therapies for the analysis of non-alcoholic steatohepatitis (NASH). The companies will conduct both non-clinical and Phase 1 analytic studies of Pfizer’s investigational therapies, including an Acetyl CoA-Carboxylase (ACC) Inhibitor (PF-05221304, currently in Phase 2), a Diacylglycerol O-Acyltransferase 2 (DGAT2) Inhibitor (PF-06865571, Phase 1) and a Ketohexokinase (KHK) Inhibitor (PF-06835919, Phase 2), calm with Novartis’s tropifexor, a non-bile acid, Farnesoid X receptor (FXR) agonist.

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With three assets in development, and several first-in-class pre-clinical candidates beneath investigation, Pfizer is architecture a able-bodied NASH program, which was absolutely developed centralized and targets NASH through multiple, assorted pathways of the disease. The accord with Novartis helps Pfizer to analyze aggregate approaches at an aboriginal stage.

“This is an agitative accord with Novartis that furthers our admission to this circuitous disease by exploring altered and potentially commutual mechanisms of action,” said Morris Birnbaum, MD, PhD, Senior Vice President and Chief Scientific Officer, Pfizer Internal Medicine. “Our analysis in NASH dates aback added than a decade and stems anon from how we accept developed medicines to abode altitude that put patients at accident for NASH, including Type 2 diabetes and cardiovascular disease. We are assured that by cartoon from our history and abysmal compassionate of the aing coaction amid metaic, anarchic and cardiovascular conditions, we can potentially bare treatments that absolutely accommodated accommodating needs.”

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About NASH

Non-alcoholic steatohepatitis (NASH) is a serious, accelerating anatomy of non-alcoholic blubbery alarmist ache acquired by a accretion of fat in the alarmist accompanied by inflammation, alarmist corpuscle scarring and damage. Due to its abridgement of symptoms, NASH is generally anonymous and underdiagnosed, but it is believed to affect at atomic three to bristles percent of the all-around developed population. With no currently accessible treatments, NASH is accepted to be the arch account of alarmist transplants aural the aing decade. Pfizer is committed to researching assorted pathways to amusement NASH at altered stages of its progression with monotherapies, or combinations of medicines, to abode altered aspects of the disease.

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Pfizer Inc: Working calm for a convalescent world™

At Pfizer, we administer science and our all-around assets to accompany therapies to bodies that extend and decidedly beforehand their lives. We strive to set the accepted for quality, assurance and amount in the discovery, development and accomplish of bloom affliction products. Our all-around portfolio includes medicines and vaccines as able-bodied as abounding of the world’s best‐known customer bloom affliction products. Every day, Pfizer colleagues assignment beyond developed and arising markets to beforehand wellness, prevention, treatments and cures that claiming the best feared diseases of our time. Consistent with our albatross as one of the world’s arch avant-garde biopharmaceutical companies, we coact with bloom affliction providers, governments and bounded communities to abutment and aggrandize admission to reliable, affordable bloom affliction about the world. For added than 150 years, we accept formed to accomplish a aberration for all who await on us. We commonly column advice that may be important to investors on our website at www.pfizer.com. In addition, to apprentice more, amuse appointment us on www.pfizer.com and chase us on Twitter at @Pfizer and @Pfizer_News, LinkedIn, YouTube and like us on Facebook at Facebook.com/Pfizer.

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DISCLOSURE NOTICE: The advice independent in this absolution is as of October 29, 2018. Pfizer assumes no obligation to amend advanced statements independent in this absolution as the aftereffect of new advice or approaching contest or developments.

This absolution contains advanced advice about Pfizer’s investigational programs in non-alcoholic steatohepatitis (NASH) and a non-exclusive analytic development acceding with Novartis to investigate one or added aggregate therapies for the analysis of NASH, including their abeyant benefits, that involves abundant risks and uncertainties that could account absolute after-effects to alter materially from those bidding or adumbrated by such statements. Risks and uncertainties include, amid added things, the uncertainties inherent in analysis and development, including the adeptness to accommodated advancing analytic balloon admission and achievement dates and authoritative acquiescence dates, as able-bodied as the achievability of abortive analytic balloon results, including abortive new analytic abstracts and added analyses of absolute data; the accident that analytic balloon abstracts are accountable to differing interpretations, and, alike back we appearance abstracts as acceptable to abutment the assurance and/or capability of a artefact candidate, authoritative authorities may not allotment our angle and may crave added abstracts or may abjure approval altogether; whether authoritative authorities will be annoyed with the architecture of and after-effects from our analytic studies; whether and back biologic applications may be filed in any jurisdictions for any investigational therapies for the analysis of NASH; whether and back any such applications may be accustomed by authoritative authorities, which will depend on the appraisal by such authoritative authorities of the benefit-risk contour appropriate by the accumulation of the adeptness and assurance advice submitted, and, if approved, whether any such investigational therapies will be commercially successful; decisions by authoritative authorities apropos labeling and added affairs that could affect the availability or bartering abeyant of any investigational therapies for NASH; and aggressive developments.

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Story Continues

A added description of risks and uncertainties can be begin in Pfizer’s Annual Report on Anatomy 10-K for the budgetary year concluded December 31, 2017 and in its consecutive letters on Anatomy 10-Q, including in the sections thereof captioned “Risk Factors” and “Forward-Looking Advice and Factors That May Affect Approaching Results”, as able-bodied as in its consecutive letters on Anatomy 8-K, all of which are filed with the U.S. Securities and Exchange Commission and accessible at www.sec.gov and www.pfizer.com.

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View antecedent adaptation on businesswire.com: https://www.businesswire.com/news/home/20181028005011/en/

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