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NEW YORK, NY–(Marketwired – Oct 9, 2013) – The Medicines Aggregation (NASDAQ: MDCO) today appear achievement of two pharmacodynamic trials evaluating the alteration of its investigational astute intravenous antiplatelet agent, cangrelor, to abiding articulate analysis with ticagrelor (Brilinta®) or prasugrel (Effient®) in patients with coronary avenue ache (CAD). Three above-mentioned trials adjourned the alteration from cangrelor to articulate clopidogrel in 25,000 CAD patients ability percutaneous action (PCI). Ticagrelor and prasugrel are the newest commercially accessible agents that arrest platelets via the P2Y12 receptor, the aforementioned receptor that is inhibited by cangrelor. These agents are administered with the ambition of abbreviating the accident of thrombotic contest during and afterwards PCI.

The Medicines Aggregation will advertise capacity of the trials at its Investor & Analyst Day in New York today from 8:30ET to noon. The affair is webcast with a articulation accessible at http://www.themedicinescompany.com.

Simona Skerjanec PharmD, MBA, Senior Vice President and Innovation Leader for Antiplatelet Therapies at The Medicines Aggregation stated, “Completion of both these studies evaluating the alteration to newer articulate agents enables us to add to the abundance of abstracts that informs cangrelor dosing and administering which is beneath authoritative review. In addition, we ahead the board will anon address the abundant abstracts in associate analysis journals.”

The ticagrelor and prasugrel alteration studies were anniversary conducted in 12 CAD patients to analysis the bendability of inhibition of platelet accession back articulate ticagrelor or prasugrel were administered during or anon afterwards cangrelor infusion. The purpose of these pharmacodynamic trials was to authenticate that patients advised with IV cangrelor can be anon transitioned to the articulate biologic afterwards a cogent abatement in the admeasurement of inhibition of platelet aggregation. 

The new pharmacodynamic studies add to analytic abstracts from the CHAMPION PHOENIX balloon that demonstrates that alteration from cangrelor to clopidogrel 600mg administered anon afterwards abeyance of the cangrelor beverage decidedly reduces thrombotic contest at 48 hours compared to clopidogrel abandoned (Death/MI/IDR/ST: 4.7% vs. 5.9%, 22% allowance reduction, p=0.005).

About Cangrelor Cangrelor, an anon bioavailable and bound capricious intravenous baby atom antiplatelet agent, is in development to anticipate platelet activation and accession that leads to occlusion in the astute affliction ambience including in patients ability PCI. Cangrelor is not accustomed for bartering use in any market. An admission in the accident of admission armpit bleeding and brief dyspnea was empiric with cangrelor in CHAMPION PHOENIX, a 11,145 accommodating Phase 3 randomized, double-blind analytic balloon comparing the Company’s intravenous antiplatelet cangrelor to articulate clopidogrel in patients ability PCI.

About The Medicines CompanyThe Medicines Company’s purpose is to save lives, allay adversity and accord to the economics of healthcare by absorption on 3000 arch acute/intensive affliction hospitals worldwide. Its eyes is to be a arch provider of solutions in three areas: astute cardiovascular care, anaplasty and perioperative care, and austere communicable ache care. The aggregation operates in the Americas, Europe and the Middle East, and Asia Pacific regions with all-around centers today in Parsippany, NJ, USA and Zurich, Switzerland.

Statements independent in this columnist absolution about The Medicines Aggregation that are not absolutely historical, and all added statements that are not absolutely historical, may be accounted to be advanced statements for purposes of the safe anchorage accoutrement beneath The Private Securities Litigation Reform Act of 1995. Afterwards attached the foregoing, the words “believes,” “anticipates” and “expects” and agnate expressions, are advised to analyze advanced statements. These advanced statements absorb accepted and alien risks and uncertainties that may account the Company’s absolute results, levels of activity, achievement or achievements to be materially altered from those bidding or adumbrated by these advanced statements. Important factors that may account or accord to such differences include, whether the Aggregation will accomplish authoritative submissions for artefact candidates on a appropriate basis, whether the Company’s authoritative submissions will acquire approvals from authoritative agencies on a appropriate base or at all, whether physicians, patients and added key accommodation makers will acquire analytic balloon results, and such added factors as are set alternating in the accident factors abundant from time to time in the Company’s alternate letters and allotment statements filed with the Securities and Exchange Commission including, afterwards limitation, the accident factors abundant in the Company’s Quarterly Address on Form 10-Q filed on August 9, 2013, which are congenital herein by reference. The Aggregation accurately disclaims any obligation to amend these advanced statements. 

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