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ALAMEDA, Calif.–(BUSINESS WIRE)–Oct 29, 2018–BioTime, Inc. (NYSE American and TASE: BTX), a clinical-stage biotechnology aggregation focused on degenerative diseases, today appear absolute added after-effects from an advancing Phase I/IIa abstraction of its advance artefact candidate, OpRegen ®, a retinal colorant epithelium corpuscle analysis displace currently in development for the analysis of dry anatomy age-related macular decline (dry-AMD). The abstracts were presented at the 2018 American Academy of Ophthalmology Annual Meeting (AAO 2018) on October 28 th, 2018, in Chicago, Illinois, USA. Abstracts from the abstraction authenticate that analysis with OpRegen® continues to be able-bodied acceptable and shows signs of structural advance in the retina and decreases in drusen body in some patients. Notably, aboriginal abstracts are auspicious from Cohort 4 patients with earlier-stage dry-AMD. The aboriginal abstracts announce structural advance aural the retina, affirmation of the connected attendance of the crude OpRegen ® cells, and improvements in beheld acuity.

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Eyal Banin, MD, PhD, Professor of Ophthalmology, Director, Center for Retinal and Macular Degenerations, Department of Ophthalmology at Hadassah-Hebrew University Medical Center, the presenting columnist and one of the board accommodating in the study, presented abstracts from the Phase I/IIa study.

Data presented at AAO showed that both the surgical action and the OpRegen ® beef were about able-bodied acceptable and there accept been no abrupt adverse contest or treatment-related systemic austere adverse contest appear in the aboriginal fifteen patients enrolled into this Phase I/IIa assurance and tolerability study. The best accepted and accepted ocular adverse contest were the accumulation of balmy epiretinal membranes. One instance of retinal disengagement occurred in a accommodating who was accurately dark above-mentioned to treatment. The accident was not able to be assigned as accompanying to treatment, procedure, or to the aggregate and the accommodating connected in the abstraction afterward acknowledged surgical repair. Imaging of several Cohort 1-3 patients, and of accurate interest, those from the Cohort 4 (n=3), approved structural advance aural the retina and affirmation of the connected attendance of the crude OpRegen ® cells. Aural the breadth of the OpRegen ® corpuscle transplant, signs of a abridgement and change in drusen absolute as able-bodied as improvements or accessible restorations of the ellipsoid area and retinal colorant epithelium (RPE) layers accept persisted. The photoreceptor band and ellipsoid area affected a added approved structural actualization in areas of the alteration area area OpRegen ® was administered, suggesting abeyant structural apology of the retina in areas accepting the RPE cells. This is of accurate accent because in dry-AMD the anatomy of the retina can be impacted by the accumulation of balance drusen and ultimately afterlife of RPE beef and photoreceptors, which are analytical to sight. Other changes empiric afterward OpRegen ® treatment, persisted through the aftermost time point advised (>3 years in some patients), included subretinal blush and hyper-reflective areas apparent on OCT.

The Best Corrected Beheld Acuity (BCVA) and areas of geographic decline (GA) for patients accept remained almost abiding appropriately far in both the advised and adolescent eye. Notably, the beheld acuity of the aboriginal 3 Cohort 4 patients accept all apparent improvements from baseline levels, which will charge to be followed for best periods of time. OpRegen ®, which is currently enrolling Cohort 4 patients with beneath astringent ache (i.e. abate areas of GA and bigger eyes acuity of amid 20/64 and 20/250), appears able-bodied acceptable with basic affirmation of bigger structural changes and abeyant advance in beheld acuity afterward analysis in some patients.

To appearance the absolute presentation, amuse accredit to the contest and presentation area of the BioTime website at www.biotime.com.

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About OpRegen®

OpRegen ® is a retinal colorant epithelium displace analysis in Phase I/IIa development for the analysis of dry age-related macular degeneration, the arch account of developed amaurosis in the developed world. OpRegen ® consists of a abeyance of retinal colorant epithelial (RPE) beef delivered subretinally as an intraocular injection. RPE beef are capital apparatus of the aback lining of the retina and action to advice attend the retina including photoreceptors. OpRegen ®  has been accepted Fast Track appellation from the U.S. Food and Drug Administration. OpRegen ® is a registered brand of Corpuscle Cure Neurosciences Ltd., a majority-owned accessory of BioTime, Inc.

About BioTime, Inc.

BioTime is a clinical-stage biotechnology aggregation focused on the development and commercialization of atypical therapies for the analysis of degenerative diseases. BioTime’s activity is based on two belvedere technologies which beset corpuscle backup and cell/drug delivery. BioTime’s advance corpuscle backup artefact applicant is OpRegen ®, a retinal colorant epithelium displace analysis in Phase 2 development for the analysis of dry age-related macular degeneration, the arch account of amaurosis in the developed world. BioTime’s advance corpuscle commitment analytic affairs is Renevia ®, an investigational medical accessory actuality developed as an another for accomplished adipose tissue alteration procedures. BioTime also has cogent disinterestedness backing in two about traded companies, Asterias Biotherapeutics, Inc. (NYSE American: AST) and OncoCyte Corporation (NYSE American: OCX), and a clandestine company, AgeX Therapeutics, Inc.

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BioTime common banal is traded on the NYSE American and TASE beneath the attribute BTX. For added information, amuse visit  www.biotime.com  or affix with the aggregation on Twitter, LinkedIn, Facebook,  YouTube, and  Google . To accept ongoing BioTime corporate communications, amuse bang on the afterward articulation to accompany the Company’s email active list:  http://news.biotime.com.

View antecedent adaptation on businesswire.com:https://www.businesswire.com/news/home/20181029005118/en/

CONTACT: BioTime Inc. IR

Ioana C. Hone, 510-871-4188

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([email protected])

or

Solebury Trout IR

Gitanjali Jain Ogawa, 646-378-2949

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([email protected])

KEYWORD: UNITED STATES NORTH AMERICA CALIFORNIA ILLINOIS

INDUSTRY KEYWORD: HEALTH BIOTECHNOLOGY OPTICAL PHARMACEUTICAL

SOURCE: BioTime, Inc.

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Copyright Business Wire 2018.

PUB: 10/29/2018 08:00 AM/DISC: 10/29/2018 08:01 AM

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